Metastatic breast cancer cells disseminate to organs with a soft microenvironment. Whether
and how the mechanical properties of the local tissue influence their response to treatment …

The role of metabolism in tumor growth and chemoresistance has received considerable
attention, however, the contribution of mitochondrial bioenergetics in migration, invasion …

Disseminated tumor cells with metabolic flexibility to utilize available nutrients in distal
organs persist, but the precise mechanisms that facilitate metabolic adaptations remain …

Mitochondria are highly dynamic and undergo constant fusion and fission that are essential
for maintaining physiological functions of cells. Although dysfunction of mitochondria has …

Mitochondrial energetics and respiration have emerged as important factors in how cancer
cells respond to or evade apoptotic signals. The study of the functional connection between …

Mitochondria control eukaryotic cell fate by producing the energy needed to support life and
the signals required to execute programed cell death. The biochemical milieu is known to …

Epithelial-to-mesenchymal transition (EMT) allows epithelial cancer cells to assume
mesenchymal features, endowing them with enhanced motility and invasiveness, thus …

Significance: Mitochondria undergo constant morphological changes through fusion, fission,
and mitophagy. As the key organelle in cells, mitochondria are responsible for numerous …

Mitochondrial dysfunction is a key feature of cancer and is frequently associated with
increased aggressiveness and metastatic potential. Recent evidence has brought to light a …

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …