H Yu, JK Mouw, VM Weaver - Trends in cell biology, 2011 - cell.com
Cancer cells exist in a constantly evolving tissue microenvironment of diverse cell types within a proteinaceous extracellular matrix. As tumors evolve, the physical forces within this …
BACKGROUND Historically, cancer has been considered a disease of the cell, caused by mutations in genes that control proliferation, differentiation, and death. In recent decades …
Biomechanical regulation of tumor phenotypes have been noted for several decades, yet the function of mechanics in the co-evolution of the tumor epithelium and altered cancer …
Highlights•Physical cues from the tumor microenvironment strongly affect cancer cell behavior.•Novel techniques increasingly help to capture those cues in vitro.•Mechanisms for …
The physical sciences and engineering have introduced novel perspectives into the study of cancer through model systems, tools, and metrics that enable integration of basic science …
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as the nucleus. A closer look inside the cells reveals that there are functional compartments or …
As tumor cells metastasize from the primary tumor location to a distant secondary site, they encounter an array of biologically and physically heterogeneous microenvironments. While …
AC Shieh - Annals of biomedical engineering, 2011 - Springer
The importance of the tumor microenvironment in cancer progression is indisputable, yet a key component of the microenvironment—biomechanical forces—remains poorly …
SC Wei, J Yang - Trends in cell biology, 2016 - cell.com
The mechanical properties of the tumor microenvironment have been increasingly recognized as potent modulators of cell behavior and function. In particular, tissue rigidity is …