Dynamic and heterogeneous interaction between tumor cells and the surrounding
microenvironment fuels the occurrence, progression, invasion, and metastasis of solid …

Tumour cell biomechanics has lately came to the fore as a disparate feature that fosters
cancer development and progression. Tumour mechanosensing entails a mechanical …

Results Cell plasticity allows adaptative strategies for cancer cells to survive or eventually
escape from tumoral environment through modification of the microenvironment–cell …

Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Mechanical features of cancer cells emerge as a distinct trait during development and
progression of solid tumors. Herein, we discuss recent key findings regarding the impact of …

Cross-talk between tumor cells and mechanical stress in the tumor microenvironment has
been shown to be involved in carcinogenesis. High mechanical stress in tumors can alter …

The tumor microenvironment (TME) plays a pivotal role in the behavior and development of
solid tumors as well as shaping the immune response against them. As the tumor cells …

Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

The tumour microenvironment contributes greatly to the response of tumour cells. It consists
of chemical gradients, for example of oxygen and nutrients. However, a physical …

The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …