Extracellular matrix stiffening of breast tissues has been clinically correlated with malignant
transformation and poor prognosis. An increase of collagen fibril diameter and lysyl-oxidase …

The behavior of cancer cells is strongly influenced by the properties of extracellular
microenvironments, including topology, mechanics and composition. As topological and …

Cell motility under physiological and pathological conditions including malignant
progression of cancer and subsequent metastasis are founded on environmental …

Collagen I is the primary extracellular matrix component of most solid tumors and influences
metastatic progression. Collagen matrix engineering techniques are useful for …

It is well established that collagen alignment in the breast tumor microenvironment provides
biophysical cues to drive disease progression. Numerous mechanistic studies have …

Abstract Architecture and microstructure of type I collagen fibers constitute central regulators
of tumor invasion with aligned fibers providing a route for migration of stromal and cancer …

Abnormal architectures of collagen fibers in the extracellular matrix (ECM) are hallmarks of
many invasive diseases, including cancer. Targeting specific stages of collagen assembly in …

While cells within tissues generate and sense 3D states of strain, the current understanding
of the mechanics of fibrous extracellular matrices (ECMs) stems mainly from uniaxial, biaxial …

Patients with mammographically dense breast tissue have a greatly increased risk of
developing breast cancer. Dense breast tissue contains more stromal collagen, which …

When cells come in contact with an adhesive matrix, they begin to spread and migrate with a
speed that depends on the stiffness of the extracellular matrix. On a flat surface, migration …