Biology, vulnerabilities and clinical applications of circulating tumour cells

A Ring, BD Nguyen-Sträuli, A Wicki, N Aceto - Nature Reviews Cancer, 2023 - nature.com
In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

[HTML][HTML] Circulating tumor cells: moving biological insights into detection

L Chen, AM Bode, Z Dong - Theranostics, 2017 - ncbi.nlm.nih.gov
Circulating tumor cells (CTCs) have shown promising potential as liquid biopsies that
facilitate early detection, prognosis, therapeutic target selection and monitoring treatment …

[HTML][HTML] Circulating tumor cell technologies

MM Ferreira, VC Ramani, SS Jeffrey - Molecular oncology, 2016 - Elsevier
Circulating tumor cells, a component of the “liquid biopsy”, hold great potential to transform
the current landscape of cancer therapy. A key challenge to unlocking the clinical utility of …

[HTML][HTML] Current approaches for avoiding the limitations of circulating tumor cells detection methods—implications for diagnosis and treatment of patients with solid …

A Kowalik, M Kowalewska, S Góźdź - Translational Research, 2017 - Elsevier
Eight million people die of cancer each year and 90% of deaths are caused by systemic
disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus …

Circulating tumor cells: a window into cancer biology and metastasis

S Maheswaran, DA Haber - Current opinion in genetics & development, 2010 - Elsevier
The presence of circulating tumor cells (CTCs) accompanies tumor invasion into the
bloodstream. Detection, monitoring, and molecular analysis of these rare cancer cells shed …

Circulating tumor cells from enumeration to analysis: Current challenges and future opportunities

YP Yang, TM Giret, RJ Cote - Cancers, 2021 - mdpi.com
Simple Summary With estimated numbers of 1–10 per mL of blood, circulating tumor cells
(CTCs) are extremely rare compared to white (a few million) or red (billions) blood cells …

Circulating tumor cells: the 'leukemic phase'of solid cancers

S Mocellin, U Keilholz, CR Rossi, D Nitti - Trends in molecular medicine, 2006 - cell.com
It is well known that malignant cells circulate in the bloodstream of patients with solid tumors.
However, the biological significance of circulating tumor cells (CTCs) and the clinical …

Circulating tumor cells: strategies for capture, analyses, and propagation

A Agarwal, M Balic, D El-Ashry, RJ Cote - The Cancer Journal, 2018 - journals.lww.com
Circulating tumor cells (CTCs) play a central role in tumor dissemination and metastases,
which are ultimately responsible for most cancer deaths. Technologies that allow for …

Circulating tumor cells: biology and clinical significance

D Lin, L Shen, M Luo, K Zhang, J Li, Q Yang… - Signal transduction and …, 2021 - nature.com
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and
extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs …

Circulating tumor cells: a review of present methods and the need to identify heterogeneous phenotypes

LM Millner, MW Linder… - Annals of Clinical & …, 2013 - Assoc Clin Scientists
The measurement and characterization of circulating tumor cells (CTCs) hold promise for
advancing personalized therapeutics. CTCs are the precursor to metastatic cancer and thus …