Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …

PGC1α is a transcriptional coactivator that is a central inducer of mitochondrial biogenesis in
cells. Recent work highlighted that PGC1α can also modulate the composition and functions …

Mitochondrial dysfunction results in high levels of oxidative stress and mitochondrial
damage, leading to disruption of endothelial homeostasis. Recent discoveries have clarified …

Aims: The transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-
1 α (PPARGC1A or PGC-1α) is a powerful controller of cell metabolism and assures the …

A key transcriptional regulator of cell metabolism, the peroxisome proliferator-activated
receptor γ co-activator 1-α (PPARGC-1-α or PGC-1α), also regulates mitochondrial …

Mechanisms responsible for energy management in the cell and in the whole organism
require a complex network of transcription factors and cofactors. Peroxisome proliferator …

The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …

Objective: Mitochondrial production of oxidants contributes to a variety of pathological
conditions including the vascular complications of diabetes, neurodegenerative diseases …

In eukaryotes, cellular and systemic metabolism is primarily controlled by mitochondrial
activity. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is an …