Mitochondrial diseases are clinically heterogeneous disorders caused by a wide spectrum
of mutations in genes encoded by either the nuclear or the mitochondrial genome …

The recent success of gene therapy across multiple clinical trials has inspired a great deal of
hope regarding the treatment of previously intractable genetic diseases. This optimism has …

Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders
that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular …

Mitochondria are best known for their role in energy production, and they are the only
mammalian organelles that contain their own genomes. The mitochondrial genome mutation …

Mitochondrial diseases are among the most common and most complex of all inherited
genetic diseases. The involvement of both the mitochondrial and nuclear genome presents …

Mitochondrial disorders comprise a molecular and clinically diverse group of diseases that
are associated with mitochondrial dysfunction leading to multi-organ disease. With recent …

Until even only a few years ago, the idea that effective therapies for human mitochondrial
disorders resulting from the dysfunction of the respiratory chain/oxidative phosphorylation …

Mitochondrial DNA diseases are common neurological conditions caused by mutations in
the mitochondrial genome or nuclear genes responsible for its maintenance. Current …

Primary mitochondrial diseases represent some of the most common and severe inherited
metabolic disorders, affecting~ 1 in 4,300 live births. The clinical and molecular diversity …

Mitochondria are dynamic bioenergetic organelles whose maintenance requires around
1500 proteins from two genomes. Mutations in either the mitochondrial or nuclear genome …