Existing long-read assemblers require thousands of central processing unit hours to
assemble a human genome and are being outpaced by sequencing technologies in terms of …

We present new methods for the improvement of long-read de novo genome assembly
incorporated into a straightforward tool called Raven (https://github. com/lbcb-sci/raven) …

The highly anticipated transition from next generation sequencing (NGS) to third generation
sequencing (3GS) has been difficult primarily due to high error rates and excessive …

Background Generating high-quality de novo genome assemblies is foundational to the
genomics study of model and non-model organisms. In recent years, long-read sequencing …

Current state-of-the-art de novo long read genome assemblers follow the Overlap-Layout-
Consensus paradigm. While read-to-read overlap–its most costly step–was improved in …

De novo genome assembly provides comprehensive, unbiased genomic information and
makes it possible to gain insight into new DNA sequences not present in reference …

Background The advent of third-generation sequencing (TGS) technologies opens the door
to improve genome assembly. Long reads are promising for enhancing the quality of …

Although most existing genome assemblers are based on de Bruijn graphs, the construction
of these graphs for large genomes and large k-mer sizes has remained elusive. This …

Background There is a rapidly increasing amount of de novo genome assembly using next-
generation sequencing (NGS) short reads; however, several big challenges remain to be …

Accurate genome assembly is hampered by repetitive regions. Although long single
molecule sequencing reads are better able to resolve genomic repeats than short-read data …