Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment
with diverse functions, including matrix deposition and remodelling, extensive reciprocal …

Simple Summary Cancer-associated fibroblasts (CAFs) are key players in the tumor
microenvironment. They are responsible for potentiating growth and metastasis through …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

Simple Summary Cancer-associated fibroblasts (CAFs) play an important contributory role in
the microenvironment of tumors. They originate from different cells, have multiple pro-and …

Simple Summary Cancer-associated fibroblasts (CAFs) are found in the tumor
microenvironment and exhibit several protumorigenic functions. Preclinical studies suggest …

Cancer-associated fibroblasts (CAFs) are an integral component of the tumor
microenvironment and have both tumor-promoting and tumor-suppressive functions. This …

Close interactions between cancer cells and cancer-associated fibroblasts (CAF) have
repeatedly been reported to support tumor progression. Yet, targeting CAFs has so far failed …

Cancer-associated fibroblasts (CAFs) are activated fibroblasts in the tumor
microenvironment. They are one of the most prominent cell types in the stroma and produce …

Abstract Cancer-associated fibroblasts (CAFs), as a central component of the tumor
microenvironment in primary and metastatic tumors, profoundly influence the behavior of …