Mechanical stimulation utilizing deep tissue-penetrating and focusable energy sources,
such as ultrasound and magnetic fields, is regarded as an emerging patient-friendly and …

Physical stimulus-responsive therapies often employing multifunctional theranostic agents
responsive to external physical stimuli such as light, magnetic field, ultra-sound …

X-ray and ultrasound waves are widely employed for diagnostic and therapeutic purposes in
clinic. Recently, they have been demonstrated to be ideal excitation sources that activate …

Mechanophores are molecular motifs that respond to mechanical perturbance with targeted
chemical reactions toward desirable changes in material properties. A large variety of …

Immunotherapy, despite its promise for future anti-cancer approach, faces significant
challenges, such as off-tumor side effects, innate or acquired resistance, and limited …

Remote control of cells and the regulation of cell events at the molecular level are of great
interest in the biomedical field. In addition to chemical compounds and genes, mechanical …

Over the past decade, researchers have highlighted the importance of mechanical cues of
the metastatic niche such as matrix stiffness, topography, mechanical stresses, and …

Magnetic nanoparticles are promising new tools for therapeutic applications, such as
magnetic nanoparticle hyperthermia therapy and targeted drug delivery. Recent in vitro …

High extracellular matrix stiffness is a prominent feature of malignant tumors associated with
poor clinical prognosis. To elucidate mechanistic connections between increased matrix …

Nanomaterials have revolutionized cancer imaging, diagnosis, and treatment.
Multifunctional nanoparticles in particular have been designed for targeted cancer therapy …