The physical characteristics of tumours are intricately linked to the tumour phenotype and
difficulties during treatment. Many factors contribute to the increased stiffness of tumours; …

Solid stress and tissue stiffness affect tumour growth, invasion, metastasis and treatment.
Unlike stiffness, which can be precisely mapped in tumours, the measurement of solid …

Biomechanical and biochemical cues within a tissue collaborate across length scales to
direct cell fate during development and are critical for the maintenance of tissue …

Mechanosensing is increasingly recognised as important for tumour progression. Tumours
become stiff and the forces that normally balance in the healthy organism break down and …

A cell undergoes many genetic and epigenetic changes as it transitions to malignancy.
Malignant transformation is also accompanied by a progressive loss of tissue homeostasis …

Cancer has been characterized as a genetic disease, associated with mutations that cause
pathological alterations of the cell cycle, adhesion, or invasive motility. Recently, the …

The tumour microenvironment contributes greatly to the response of tumour cells. It consists
of chemical gradients, for example of oxygen and nutrients. However, a physical …

Increased tissue stiffness is a classic characteristic of solid tumors. One of the major
contributing factors is increased density of collagen fibers in the extracellular matrix (ECM) …

Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …

Oncologists often diagnose cancer based on a change of tissue stiffness sensed by
palpation, yet cancer researchers generally focus on biochemical signaling mechanisms …