Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Conspectus T cells, a key component in adaptive immunity, are central to many
immunotherapeutic modalities aimed at treating various diseases including cancer …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

T cell immune responses are critical for in both physiological and pathological processes.
While biochemical cues are important, mechanical cues arising from the microenvironment …

Mechanical forces in the tumor microenvironment (TME) are associated with tumor growth,
proliferation, and drug resistance. Strong mechanical forces in tumors alter the metabolism …

Immunotherapy, despite its promise for future anti-cancer approach, faces significant
challenges, such as off-tumor side effects, innate or acquired resistance, and limited …

Immune cell recognition of antigens is a pivotal process in initiating immune responses
against injury, pathogens, and cancers. Breakthroughs over the past decade support a …

Within the complex tumor microenvironment, cells experience mechanical cues—such as
extracellular matrix stiffening and elevation of solid stress, interstitial fluid pressure, and fluid …

Immune cells can sense and respond to biophysical cues—from dynamic forces to spatial
features—during their development, activation, differentiation and expansion. These …

Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …