The extracellular matrix (ECM) performs many critical functions, one of which is to provide
structural and mechanical integrity, and many of the constituent proteins have clear …

The tumor microenvironment (TME) is a complex macromolecular network filled with a series
of stromal cells. It plays an important role in tumorigenesis, development, immune escape …

Tumor progression in vitro has traditionally been studied in the context of two-dimensional
(2D) environments. However, it is now well accepted that 2D substrates are unnaturally rigid …

Alteration in the density and composition of extracellular matrix (ECM) occurs in tumors. The
alterations toward both stiffness and degradation are contributed to tumor growth and …

The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical
and biophysical properties that influence cell phenotype. The ECM is highly dynamic as it is …

Little is known about the complex interplay between the extracellular mechanical
environment and the mechanical properties that characterize the dynamic intracellular …

The cancer cells obtain their invasion potential not only by genetic mutations, but also by
changing their cellular biophysical and biomechanical features and adapting to the …

During the last decades, cell mechanics has been recognized as a quantitative measure to
discriminate between many physiological and pathological states of single cells. In the field …

The tumor microenvironment (TME) is gaining increasing attention in oncology, as it is
recognized to be functionally important during tumor development and progression. Tumors …