Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts

A Tosaki, IE Blasig, T Pali, B Ebert - Free Radical Biology and Medicine, 1990 - Elsevier
The purpose of this study was to use a direct method, that of electron spin resonance (ESR)
spectroscopy, to demonstrate that reperfusion after a period of ischemia results in a sudden …

Singlet oxygen and myocardial injury: ultrastructural, cytochemical and electrocardiographic consequences of photoactivation of rose bengal

G Vandeplassche, M Bernier, F Thoné… - Journal of molecular and …, 1990 - Elsevier
Photoactivation of rose bengal leads to the generation of reactive oxygen intermediates
(predominantly singlet oxygen with some superoxide anion) which are potentially injurious …

Exacerbation of reperfusion arrhythmias by sudden oxidant stress.

Y Kusama, M Bernier, DJ Hearse - Circulation research, 1990 - Am Heart Assoc
A burst of free oxygen radical production has been demonstrated during the early moments
of reperfusion, coincident with the onset of reperfusion arrhythmias, which can be attenuated …

Electrophysiological and arrhythmogenic effects of platelet activating factor during normal perfusion, myocardial ischaemia and reperfusion in the guinea‐pig

NA Flores, DJ Sheridan - British journal of pharmacology, 1990 - Wiley Online Library
1 Platelet activating factor (PAF) is often used to study the effects of platelet activation. While
direct myocardial electrophysiological effects of PAF have been described in superfused …

Are reperfusion-induced arrhythmias caused by disinhibition of an arrhythmogenic component of ischemia?

T Nakata, DJ Hearse, MJ Curtis - Journal of molecular and cellular …, 1990 - Elsevier
Isolated rat hearts were used to examine whether reperfusion-induced arrhythmias may be
caused by washout of substances accumulating during ischemia. This was achieved by …

Enhanced α‐adrenoceptor responsiveness and receptor number during global ischaemia in the Langendorff perfused rat heart

MC Butterfield, R Chess‐Williams - British journal of …, 1990 - Wiley Online Library
1 Idioventricular rate responses and adrenoceptor number have been examined in normal
Langendorff hearts perfused at 70 cmH2O and in 'ischaemic'hearts perfused at 10 cmH2O. 2 …

The detection of technical failures in perfused heart with ischemia and reperfusion by epicardial NADH fluorescence

KK Minezaki, Y Shinozaki, H Nakazawa, Y Yamada… - Heart and vessels, 1990 - Springer
This study documents the value of continuous observation of nicotinamide adenine
dinucleotide (NADH) fluorescence (NADH-F). NADH-F monitoring is used to identify …

Effect of iloprost on reperfusion-induced arrhythmias and myocardial ion shifts in isolated rat hearts

A Tosaki, M Koltai, M Paubert-Braquet - European journal of pharmacology, 1990 - Elsevier
Isolated hearts excised from normotensive (NT) and spontaneously hypertensive (SH) rats
subjected to transient normothermic global ischemia were used to study the effect of chronic …

Species differences in vulnerability to injury by oxidant stress: a possible link with calcium handling?

T Nakata, DJ Hearse - Cardiovascular research, 1990 - academic.oup.com
Study objective–The aim was to exploit species-and age dependent differences in calcium
handling to assess the role of calcium as a mediator of oxidant stress induced injury in the …

THE MECHANISM OF PROTECTIVE EFFECT OF DILTIAZEM ON REPERFUSION-INDUCED ARRHYTHMIAS IN ISOLATED RAT HEART: 51st Annual Meeting of the …

A MITANI, K KINOSHITA, Y TOSHIMA… - Japanese Circulation …, 1990 - jstage.jst.go.jp
MATERIALS AND METHODS 1. Experimental animals and apparatus Wistar rats (250—
350g) were anesthetized with diethyl ether. Sodium heparin (200U) was injected …