Studies using chemically-induced models of diabetes have shown the diabetic myocardium
to exhibit abnormalities in cellular ion transport, which may affect susceptibility to reperfusion …

The role of anions in the initiation of ischemia-and reperfusion-induced arrhythmias is
unknown. We examined the antiarrhythmic effects of isotonic substitution of extracellular Cl …

The antiarrhythmic actions of low and high doses of U-50,488 H, a selective κ-receptor
agonist, were examined in pentobarbitone-anaesthetized rats subjected to occlusion of the …

To investigate a possible protective role of Na+/H+ exchange inhibition under ischemic
conditions isolated rat hearts were subjected to regional ischemia and reperfusion. In these …

Rapid washout of extracellular H+ accumulated during preceding ischemia (ie, the abrupt
restoration of extracellular pH) has been implicated as an arrhythmogenic factor during …

The antiarrhythmic activities of 16-methylcyprenorphine (M8008), nor-binaltorphimine (NBT)
and naltrexone, which are relatively specific opioid receptor antagonists for δ, κ and μ …

Tedisamil is a new bradycardic agent, previously shown to block transient outward and
delayed rectifier potassium currents in cardiac tissue [1, 2]. In the present study tedisamil …

The objectives of this study were to test the hypothesis that dynorphin in the central nervous
system modulates epinephrine-induced cardiac arrhythmias and that central cholinergic …

Pinacidil is a member of the new antihypertensive drug family possessing an action that
involves an increased, potassium efflux in vascular and cardiac muscle. We investigated the …

The antiarrhythmic actions of the racemate and enantiomers of mexiletine were studied in
conscious and anaesthetised rats. Racemate or enantiomers, at 20 mg/kg iv, had little effect …