The immunology of exceptional individuals: the lesson of centenarians

C Franceschi, D Monti, P Sansoni, A Cossarizza - Immunology today, 1995 - cell.com
Centenarians are the best example of successful ageing, since they have escaped the major
age-associated diseases, alzd most are in good mental and physical condition. Heye …

Immunosenescence in humans: deterioration or remodelling?

C Franceschi, D Monti, D Barbieri… - International Reviews …, 1995 - Taylor & Francis
CLAUDIO FRANCESCHI,? DANIELA MONTI,? DANIELA BARBIERI,? EMANUELA
GRASSILLI,? LEONARDA TROIAN0, t STEFANO SALVIOL1, t PAOLO NEGRO,? MIRIAM …

Hypercoagulability in centenarians: the paradox of successful aging

D Mari, PM Mannucci, R Coppola, B Bottasso… - 1995 - ashpublications.org
With advancing age, an increasing number of healthy individuals have laboratory signs of
heightened coagulation enzyme activity. Such biochemical hypercoagulability might be the …

Cytokine production and lymphocyte subpopulations in aged humans. An assessment during nocturnal sleep

J Born, D Uthgenannt, C Dodt, D Nünninghoff… - Mechanisms of ageing …, 1995 - Elsevier
The view of a general impairment of immune functions associated with aging has been
challenged by recent studies including a more detailed evaluation of various cytokines and …

Depression in caregivers of demented patients is associated with altered immunity: impaired proliferative capacity, increased CD8+, and a decline in lymphocytes with surface signal transduction …

S Castle, S Wilkins, E Heck, K Tanzy… - Clinical & Experimental …, 1995 - academic.oup.com
Changes in relevant immune parameters, including function, were found to be associated
with depression in elderly caregiver wives of demented patients. We studied the relationship …

Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans

IM Jones, CB Thomas, B Tucker, CL Thompson… - Mutation Research …, 1995 - Elsevier
Analysis of two human populations for dependence of somatic mutation on age has
revealed both similarities and differences. The studies performed employed peripheral …

Introduction: the reshaping of the immune system with age

C Franceschi, A Cossarizza - International reviews of immunology, 1995 - Taylor & Francis
In the last decades major theoretical and technological advances have been achieved in the
field of immunology. They allowed the scientific community to analyze the immune system in …

Circulating CD20dim T‐lymphocytes increase with age: evidence for a memory cytotoxic phenotype

I Storie, GA Wilson, V Granger… - Clinical & Laboratory …, 1995 - Wiley Online Library
The CD20 antigen has been regarded as a B lineage specific, 35 kDa, non‐glycosylated
membrane phosphoprotein, which functions as either a Ca2+ ion channel or as a regulatory …

The use of non-radioactive chromium as an alternative to 51Cr in NK assay

P Borella, A Bargellini, S Salvioli, CI Medici… - Journal of …, 1995 - Elsevier
A novel method to measure target cell cytolysis based on the use of 'cold', non-radioactive
chromium and on the determination of metal release by graphite furnace atomic absorption …

Age-related changes in mitogen-induced β-endorphin release from human peripheral blood mononuclear cells

B Manfredi, E Clementi, P Sacerdote, M Bassetti… - Peptides, 1995 - Elsevier
β-Endorphin is an opioid peptide synthesized in the pituitary, hypothalamus, and
immunocytes, known to affect immune responses both when added in vitro and when its …