Our understanding of the role of hemidesmosomes in cell—substratum adhesion has greatly
improved both as a result of targeted gene mutation experiments and by means of …

Les intégrines, une famille de récepteurs assurant l'adhésion, jouent un rôle important dans
l'organisation et la fonction de l'épithélium. Des modifications de l'expression ou de la …

Integrins are heterodimeric transmembrane glyco-proteins which are engaged in a variety of
cellular functions, such as adhesion, migration and differentiation1. The integrin α6β4 is …

Ex vivo expansion of human fetal pancreatic endocrine cells is important for biological
studies and as a potential tissue source for transplantation in insulin-deficient states. In …

Hemidesmosomes are complex macromolecular structures which integrate elements of the
extracellular matrix and the cytoskeleton of epithelial cells. To characterize cell-matrix …

Herlitz junctional epidermolysis bullosa (H-JEB) is characterized by a reduced adherence of
keratinocytes consequent to deficient expression of the extracellular adhesive ligand laminin …

Laminin-5r is a basement membrane component that promotes rapid adhesion and
hemidesmosome formation in epithelial cells. We raised monoclonal antibodies and …

In this dissertation, I have studied epithelial cell attachment to the basement membrane via a
structure called the hemidesmosome. I first investigated a role for laminin-5 in the assembly …