A large number of glycoprotein (GP) IIb/IIIa receptors are present on the surface of platelets.
Studies to define precisely the number of GPIIb/IIIa receptors using specific monoclonal …

Rapid and yet precisely controlled changes in cell adhesion are a hallmark of a number of
basic physiological processes. Many of these processes directly impact upon nephrology …

A novel inhibitor of human platelet aggregation, named variabilin, was isolated from salivary
glands of the hard tick Dermacentor variabilis using a combination of gel filtration and high …

Fibulin-1 is a component of the extracellular matrix that surrounds vascular smooth muscle.
This observation, along with the recent finding that fibulin-1 can bind fibrinogen (J Biol Chem …

Qualitative platelet disorders are the diseases which show prolonged bleeding time and
bleeding tendency due to platelet dysfunction in association with normal platelet counts …

Platelet-agonist interaction results in activation of glycoprotein (GP) IIb-IIIa complex and
fibrinogen binding, a prerequisite for platelet aggregation. Fibrinogen binding exposes new …

Two disintegrins with a high degree of amino acid sequence similarity, echistatin and
eristostatin, showed a low level of interaction with Chinese hamster ovary (CHO) cells, but …

Glanzmann thrombasthenia (GT), an autosomal recessive bleeding disorder, results from
abnormalities in the platelet fibrinogen receptor, GP (IIb)-IIIa (integrin alpha (IIb) beta3). A …

We characterized a murine monoclonal antibody, PT25-2 (IgG 1), raised against washed
human platelets. The antibody and its Fab fragments were both capable of inducing platelet …

The integrin α IIb β 3, a calcium-dependent heterodimer, plays a critical role in platelet
aggregation. The α IIb subunit of the heterodimer contains four highly conserved putative …