Glucagon-like peptide 1 undergoes differential tissue-specific metabolism in the anesthetized pig

CF Deacon, L Pridal, L Klarskov… - American Journal of …, 1996 - journals.physiology.org
Glucagon-like peptide 1 (GLP-1) metabolism was studied in halothane-anesthetized pigs
(n= 7) using processing-independent (PI) and COOH-terminal (C) radioimmunoassays (RIA) …

Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7–36 amide]) in patients with NIDDM

MA Nauck, D Wollschläger, J Werner, JJ Holst… - Diabetologia, 1996 - Springer
Intravenous glucagon-like peptide (GLP)-1 [7–36 amide] can normalize plasma glucose in
non-insulin-dependent diabetic (NIDDM) patients. Since this is no form for routine …

Potential therapeutic levels of glucagon-like peptide I achieved in humans by a buccal tablet

MK Gutniak, H Larsson, SJ Heiber… - Diabetes …, 1996 - Am Diabetes Assoc
OBJECTIVE Glucagon-like peptide I (7–36)(GLP-I) amide, an endogenous incretin, has
been identified as a potential adjunct to the treatment of NIDDM and has been studied …

Glucagon-like peptide-1 (7–37) has a larger volume of distribution than glucagon-like peptide-1 (7–36) amide in dogs and is degraded more quickly in vitro by dog …

L Pridal, CF Deacon, O Kirk, JV Christensen… - European Journal of …, 1996 - Springer
The pharmacokinetic properties of glucagon-like peptide-1 (7–36) amide and GLP-1 (7–37)
were compared. Four beagle dogs received on 4 separate occasions sc bolus doses of 50 …

Absorption of glucagon-like peptide-1 can be protracted by zinc or protamine

L Pridal, H Agerbæk, LN Christensen… - International journal of …, 1996 - Elsevier
Pharmacokinetics of several different preparations for subcutaneous administration of GLP-1
(7–36) amide (GLP-1) were studied. The difference between soluble GLP-1 at pH 4.0 and a …

Potential of GLP-1 in diabetes management

JJ Holst, MA Nauck, CF Deacon, C Ørskov - Glucagon III, 1996 - Springer
As reviewed in Chap. 3, this volume, glucagon-like peptide-1 (GLP-1) is the designation
given to the sequence in proglucagon corresponding to residues Nos. 72–108 (Bell et al …

Investigation of metabolism of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) by dipeptidyl peptidase IV (DP IV)

RP Pauly - 1996 - open.library.ubc.ca
The incretins glucose-dependent insulinotropic polypeptide (GTP1-42) and truncated forms
of glucagon-like peptide-1 (GLP-I7-36 and GLP-I7. 37) are hormones released from the gut …

[引用][C] On the effects of glucagon‐like peptide‐1 on blood glucose regulation in normal and diabetic subjects

JJ Holst, MAJB TOFT‐NIELSEN… - Annals of the New …, 1996 - Wiley Online Library
FIGURE 1. Schematic representation of the differential processing of proglucagon as it
occurs in the pancreatic islets and in the intestinal mucosa in man. The vertical lines in …