The molecular origin of standard metabolic rate and thermogenesis in mammals is
examined. It is pointed out that there are important differences and distinctions between the …

Superoxide Production by the Mitochondrial Respiratory Chain Page 1 Bioscience Reports,
Vol. 17, No. 1, 1997 REVIEW Superoxide Production by the Mitochondrial Respiratory …

A significant amount of reactive oxygen species (ROS) is generated during mitochondrial
oxidative phosphorylation. Several studies have suggested that mtDNA may accumulate …

In postindustrial societies, overeating, inactivity, and obesity have emerged as new
challenges in public health. 1, 2 Considerable effort is now being devoted to determining the …

Oxidative stress has been implicated in both normal aging and in various
neurodegenerative disorders and may be a common mechanism underlying various forms …

2, 7-Dichlorodihydrofluorescein (DCDHF), commonly known as dichlorofluorescin, and
dihydrorhodamine 123 (DHR) are often used to detect the production of reactive nitrogen …

Mitochondrial function can be manipulated selectively by targeting bioactive compounds to
mitochondria in living cells. Current targeting mechanisms involve harnessing either the …

We have examined the substrate specificity and inhibitor sensitivity of H 2 O 2 formation by
rat heart mitochondria. Active H 2 O 2 production requires both a high fractional reduction of …

Mitochondria generate reactive oxygen species (ROS) as byproducts of molecular oxygen
consumption in the electron transport chain. Most cellular oxygen is consumed in the …

Lipoic acid (thiotic acid) is being used as a dietary supplement, and as a therapeutic agent,
and is reported to have beneficial effects in disorders associated with oxidative stress, but its …