The phosphorylated acidic glycoprotein osteopontin is present in the extracellular matrix of
atherosclerotic plaques and the wall of injured but not normal arteries. To determine if …

Platelet responses to thrombin are at least partly mediated by a G-protein-coupled receptor
whose NH 2 terminus is a substrate for thrombin. In the present studies we have examined …

G proteins play a major role in signal transduction upon platelet activation. We have
previously reported a patient with impaired agonist-induced aggregation, secretion …

Integrin α IIb β 3 functions as the fibrinogen receptor on platelets and mediates platelet
aggregation and clot retraction. Among the events that occur during either" inside-out" or" …

The benzodiazepinedione class of non-peptidal GPIIbIIIa antagonists has been modified to
allow the isolation of noninterconverting rotational isomers, or atropisomers, with the aim of …

The deposition of a platelet rich thrombus on an atherosclerotic plaque is a critical step in
the development of unstable coronary syndromes. Currently available therapeutic agents …

It is demonstrated that the acyl-CoA: cholesterol acyltransferase (ACAT) enzyme activity in
rough endoplasmatic reticulum membranes is regulated by the acyl-CoA binding protein …

A novel peptide (designed to bind to αIIbβ3) caused platelet aggregation and aggregation-
independent secretion of the contents of α-granules in an αIIbβ3-dependent fashion. The …

We report a case of Glanzmann thrombasthenia in a Pakistani child whose platelets express
less than 10% of the normal amount of αIIbβ3 on their surface. Single-stranded conformation …

In this study, endothelial cell-mediated clot retraction was supported by fibrin generated from
several purified fractions of plasma fibrinogen, purified proteolytic fragments of plasma …