1. Vasodilatation induced by adenosine is mediated through the activation of A2‐
purinoceptors in endothelial and smooth muscle cells. 2. Adenosine induces a rapid and …

To evaluate the effect of angiotensin-converting inhibition enzyme on spontaneous and
insulin-stimulated endothelin-1 (ET-1) secretion in vitro and in vivo, human endothelial cells …

Increased levels of endothelin (ET-1), a potent endothelium-derived vasoconstrictive
peptide, have been found in plasma from non-insulin dependent diabetic (NIDDM) patients …

Several lines of evidence suggest that effects of angiotensin-II (A-II) could be mediated in
part by endothelin-1 (ET-1): A-II enhances production and secretion of ET-1 which in turn …

Circulating endothelin-1 concentration was evaluated in 93 lean patients with essential
hypertension, of whom 16 had impaired glucose tolerance and hyperlipidaemia, 25 had …

Elevations in circulating levels of both endothelin-1 (ET-1) and insulin are found in coronary
heart disease and chronic heart failure. Although several studies have shown that insulin …

Endothelin (ET) is a peptide with profound vasoconstrictive potential. First isolated from
porcine endothelial cell supernatant, it is produced also by smooth muscle, epithelial and …

Several studies point to a role for endothelin‐1 (ET‐1) in enhancing adhesion molecule
expression and leucocyte adhesion. We thus hypothesized that ET‐1 would induce …

The endothelium‐derived peptide endothelin‐1 (ET‐1) was evaluated in 14 male patients
[mean age 52.74 years (SEM 1.10)] affected by coronary artery disease during a bicycle …

The maintenance of vascular tone is extremely complex. Neural, endocrine, paracrine, and
mechanical depressor and pressor forces all participate in a delicate balancing act to …