Toward understanding the molecular pathology of Huntington's disease
CL Wellington, RR Brinkman, JR O'Kusky… - Brain …, 1997 - Wiley Online Library
Huntington's Disease (HD) is caused by expansion of a CAG trinucleotide beyond 35
repeats within the coding region of a novel gene. Recently, new insights into the relationship …
repeats within the coding region of a novel gene. Recently, new insights into the relationship …
Therapeutic strategies for Huntington's disease based on a molecular understanding of the disorder
NSK Haque, P Borghesani, O Isacson - Molecular Medicine Today, 1997 - cell.com
A mutation on chromosome 4p16. 3 with an expanded polyglutamine tract has been
identified as the cause of Huntington's disease (HD). The neuroscience and clinical …
identified as the cause of Huntington's disease (HD). The neuroscience and clinical …
Huntingtin immunoreactivity in the rat neostriatum: differential accumulation in projection and interneurons
CM Kosinski, JH Cha, AB Young, F Persichetti… - Experimental …, 1997 - Elsevier
Huntington's disease is caused by a mutation of the gene encoding the protein huntingtin.
Features of the human disease, characterized by selective loss of neurons from the …
Features of the human disease, characterized by selective loss of neurons from the …
Age-dependent differences in survival of striatal somatostatin–NPY–NADPH–diaphorase-containing interneurons versus striatal projection neurons after Intrastriatal …
G Figueredo-Cardenas, Q Chen, A Reiner - Experimental neurology, 1997 - Elsevier
Some authors have reported greater sparing of neurons containing somatostatin (SS)–
neuropeptide Y (NPY)–NADPH-diaphorase (NADPHd) than projection neurons after …
neuropeptide Y (NPY)–NADPH-diaphorase (NADPHd) than projection neurons after …
Expression and distribution of the dentatorubral-pallidoluysian atrophy gene product (atrophin-1/drplap) in neuronal and non-neuronal tissues
SP Knight, MM Richardson, AP Osmand… - Journal of the …, 1997 - Elsevier
Utilizing an affinity-purified antiserum directed against the carboxyl terminal region of
atrophin-1/drplap (residues 1170–1185), we have examined the expression and distribution …
atrophin-1/drplap (residues 1170–1185), we have examined the expression and distribution …