Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies

S Wan, JL LeClerc, JL Vincent - Chest, 1997 - Elsevier
Background Recent study of the inflammatory reactions occurring during and after
cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the …

Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction

JM Rapola, J Virtamo, S Ripatti, JK Huttunen… - The Lancet, 1997 - thelancet.com
Background Epidemiological data suggest that the intake of antioxidants such as α-
tocopherol (vitamin E) and β-carotene has an inverse correlation with the incidence of …

Ischaemic preconditioning reduces troponin T release in patients undergoing coronary artery bypass surgery.

DP Jenkins, WB Pugsley, AM Alkhulaifi, M Kemp… - Heart, 1997 - heart.bmj.com
OBJECTIVE: To investigate whether ischaemic preconditioning could reduce myocardial
injury, as manifest by troponin T release, in patients undergoing elective coronary artery …

Oral sulfonylurea hypoglycemic agents prevent ischemic preconditioning in human myocardium: two paradoxes revisited

JC Cleveland Jr, DR Meldrum, BS Cain, A Banerjee… - Circulation, 1997 - Am Heart Assoc
Background Patients receiving oral hypoglycemic agents for diabetes mellitus are at
increased risk of cardiovascular mortality. Oral hypoglycemic agents are inhibitors of the …

Signal transduction in ischemic preconditioning

JM Downey, MV Cohen - Analytical and Quantitative Cardiology, 1997 - Springer
Ischemic preconditioning is a phenomenon in which exposure of the heart to a brief period
of ischemia causes it to quickly adapt itself to become resistant to infarction from a …

Ischemic preconditioning decreases apoptosis in rat hearts in vivo

CA Piot, D Padmanaban, PC Ursell, RE Sievers… - Circulation, 1997 - Am Heart Assoc
Background Previous studies have demonstrated that ischemic preconditioning prevents
lethal cell injury and, as a consequence, limits infarct size in rat heart. Although both …

Implications of prodromal angina pectoris in anterior wall acute myocardial infarction: acute angiographic findings and long-term prognosis

M Ishihara, H Sato, H Tateishi, T Kawagoe… - Journal of the American …, 1997 - jacc.org
Objectives. This study was undertaken to assess how prodromal angina affects long-term
prognosis after acute myocardial infarction. Background. Although it has been reported that …

Safety, tolerance, and efficacy of adenosine as an additive to blood cardioplegia in humans during coronary artery bypass surgery

RM Mentzer Jr, PS Rahko, V Molina-Viamonte… - The American journal of …, 1997 - Elsevier
Myocardial stunning after heart surgery is associated with increased morbidity and mortality
in patients with severe multivessel disease and reduced myocardial function. The purpose of …

Role of Kinins in the Cardioprotective Effect of Preconditioning: Study of Myocardial Ischemia/Reperfusion Injury in B2 Kinin Receptor Knockout Mice and Kininogen …

XP Yang, YH Liu, GM Scicli, CR Webb… - Hypertension, 1997 - Am Heart Assoc
Kinins acting on the B2 receptor appear to be involved in the cardioprotective effect of
preconditioning on myocardial ischemia/reperfusion injury. We tested the hypothesis that in …

Changes in ischemic tolerance and effects of ischemic preconditioning in middle-aged rat hearts

M Tani, Y Suganuma, H Hasegawa, K Shinmura… - Circulation, 1997 - Am Heart Assoc
Background Although both clinical and animal studies have shown that ischemic tolerance
is reduced in the senescent myocardium, it has not been clarified when myocardium …