ALTHOUGH MANY ASPECTS of the development of malignant tumors are still incompletely
understood, conditions have been identified under which malignancies develop at a higher …

PURPOSE: The principal objectives of this study were to estimate the incidence of second
tumors among children treated for heritable retinoblastoma during a 50-year period and to …

PURPOSE To evaluate the incidence of and potential risk factors for second malignant
neoplasms of the brain following treatment for childhood acute lymphoblastic leukemia …

Seventy-four patients who had a Ewing sarcoma of bone were managed with preoperative
and postoperative chemotherapy and operative resection, with or without postoperative …

PURPOSE To define the magnitude of second cancer risk among pediatric Hodgkin's
disease survivors and to determine which factors influence this risk. PATIENTS AND …

Purpose: To determine if involved field radiation (IF) is equivalent to standard whole bone
radiation (SF) in local tumor control; to establish patterns of failure following treatment; and …

Osteosarcoma is the most frequent second primary cancer occurring during the first 20 years
following treatment for a solid cancer in childhood. Using a cohort study of children treated …

We report a prospective, randomised, blinded clinical comparison of the use of
indomethacin or radiation therapy for the prevention of heterotopic ossification (HO) in 75 …

BACKGROUND Surgical resection and adjuvant radiation therapy are standard therapy for
soft tissue sarcomas. When the tumor approximates bone, periosteal excision may be …

The development of neoplasms subsequent to therapeutic cranial irradiation is a rare but
serious and potentially fatal complication. In this study, we retrospectively reviewed the …