Characterisation, utilisation and clinical relevance of isolated perfused heart models of ischaemia-induced ventricular fibrillation

MJ Curtis - Cardiovascular Research, 1998 - academic.oup.com
The isolated perfused heart has been used increasingly during the last decade as a model
for identifying actions of drugs on ventricular fibrillation (VF) induced by myocardial …

Exercise training improves myocardial tolerance to in vivo ischemia-reperfusion in the rat

SK Powers, HA Demirel, HK Vincent… - American Journal …, 1998 - journals.physiology.org
Experimental studies examining the effects of regular exercise on cardiac responses to
ischemia and reperfusion (I/R) are limited. Therefore, these experiments examined the …

Ischemia/reperfusion‐induced arrhythmias in the isolated rat heart: prevention by melatonin

DX Tan, LC Manchester, RJ Reiter, W Qi… - Journal of pineal …, 1998 - Wiley Online Library
Cardiac arrhythmias during ischemia/reperfusion are believed to be related to free radicals
generated in the heart especially during the period of reperfusion. Since melatonin functions …

Effects of enflurane, isoflurane, sevoflurane and desflurane on reperfusion injury after regional myocardial ischaemia in the rabbit heart in vivo

B Preckel, W Schlack, T Comfere, D Obal… - British journal of …, 1998 - Elsevier
It is known that volatile anaesthetics protect myocardial tissue against ischaemic and
reperfusion injury in vitro. In this investigation, we have determined the effects of the …

Whole-body hyperthermia provides biphasic cardioprotection against ischemia/reperfusion injury in the rat

N Yamashita, S Hoshida, N Taniguchi, T Kuzuya… - Circulation, 1998 - Am Heart Assoc
Background—Hyperthermia increases cardiac tolerance to ischemia/reperfusion injury 24
hours after the heat stress. Free radicals and redox mechanisms have been implicated in …

[HTML][HTML] Effects of EGb 761 on nitric oxide and oxygen free radicals, myocardial damage and arrhythmia in ischemia-reperfusion injury in vivo

J Shen, J Wang, B Zhao, J Hou, T Gao, W Xin - Biochimica et Biophysica …, 1998 - Elsevier
The cardioprotective effects of EGb 761 on the release of nitric oxide (NO), the concentration
of serum thiobarbituric acid reaction substance (TBARS), the activity of creatine kinase (CK) …

Trace elements and cardioprotection: increasing endogenous glutathione peroxidase activity by oral selenium supplementation in rats limits reperfusion-induced …

S Tanguy, F Boucher, S Besse, V Ducros… - Journal of trace …, 1998 - Elsevier
Oxyradicals have been implicated as a possible cause of reperfusion-arrhythmias (RA).
However, the use of diverse exogenous oxyradical scavengers designed to reduce RA has …

Endothelin and ischaemic arrhythmias–antiarrhythmic or arrhythmogenic?

I Sharif, KA Kane, CL Wainwright - Cardiovascular research, 1998 - academic.oup.com
Objective: The aim of this study was to investigate the influence of endogenously released
and exogenously applied endothelin-1 (ET-1) on ischaemia-induced arrhythmias. Methods …

Effects of reperfusion on arrhythmias and death after coronary artery occlusion in the rat: increased electrical stability independent of myocardial salvage

CF Opitz, PV Finn, MA Pfeffer, GF Mitchell… - Journal of the American …, 1998 - jacc.org
Objectives. This study sought to delineate salvage-dependent from salvage-independent
coronary reperfusion in acute myocardial infarction and the effects on spontaneously …

Differential effects of paclitaxel and derivatives on guinea pig isolated heart and papillary muscle

G Alloatti, C Penna, MP Gallo, RC Levi… - … of Pharmacology and …, 1998 - ASPET
Paclitaxel (Taxol) is an anticancer agent with clinical activity against various human cancer
types. Paclitaxel blocks cell division by stabilizing microtubules, a mechanism that also …