▪ Abstract The tight junction creates a regulated barrier in the paracellular pathway and,
together with the actin-rich adherens junction, forms a functional unit called the apical …

Forty years of research into the function of l-glutamic acid as a neurotransmitter in the
vertebrate central nervous system (CNS) have uncovered a tremendous complexity in the …

The tight junction protein ZO-1 belongs to a family of multidomain proteins known as the
membrane-associated guanylate kinase homologs (MAGUKs). ZO-1 has been …

Specific patterns of neuronal firing induce changes in synaptic strength that may contribute
to learning and memory. If the postsynaptic NMDA (N-methyl-d-aspartate) receptors are …

Abstract The PSD-95/SAP90 family of proteins has recently been implicated in the
organization of synaptic structure. Here, we describe the isolation of a novel Ras-GTPase …

Mice lacking the voltage-gated potassium channel α subunit, KV 1.1, display frequent
spontaneous seizures throughout adult life. In hippocampal slices from homozygous KV 1.1 …

Occludin is the only known integral membrane protein of tight junctions (TJs), and is now
believed to be directly involved in the barrier and fence functions of TJs. Occludin-deficient …

A 130-kD protein that coimmunoprecipitates with the tight junction protein ZO-1 was bulk
purified from Madin-Darby canine kidney (MDCK) cells and subjected to partial …

We identify a complex of three proteins in brain that has the potential to couple synaptic
vesicle exocytosis to neuronal cell adhesion. The three proteins are:(1) CASK, a protein …

The gap junction protein connexin-43 is normally located at the intercalated discs of cardiac
myocytes, and it plays a critical role in the synchronization of their contraction. The …