Ischemic preconditioning, a powerful form of endogenous protection against myocardial
infarction, has been demonstrated in several animal species and, recently, in isolated …

OBJECTIVES The purpose of this study was to determine whether administration of
bradykinin reproduces the cardioprotective effects of ischemic preconditioning (PC) in …

OBJECTIVES We attempted to establish whether naloxone, an opioid receptor antagonist,
abolishes the adaptation to ischemia observed in humans during coronary angioplasty after …

The phenomenon of ischaemic preconditioning, highlights a new and endogenous route to
myocardial protection, which we believe could be exploited in our search for new …

Background—Previous studies in humans have indicated that there is less ischemic
dysfunction during PTCA when ischemic preconditioning is elicited. However, the clinical …

During coronary angioplasty, a stair-step decrease in peak ST segment elevation from the
first to the second coronary occlusion has been assumed to indicate a preconditioning (PC) …

Adenosine is released in large amounts during myocardial ischemia and is capable of
exerting potent cardioprotective effects in the heart. Although these observations on …

A variety of experimental studies have confirmed that preconditioning the myocardium by
brief periods of ischemia represents a powerful cardioprotective effect resulting in a …

H. Thomas Lee, MD, PhD p ROLONGED and sustained ischemia produces cell death and
tissue infarction in all organ systems. Originally, the dogma was that only prompt reperfusion …

The concept of ischemic preconditioning refers to myocardial protection from ischemia-
reperfusion insult by preceding brief ischemic episodes (1). An extensive effort has been …