Huntington's disease (HD) is an inherited, autosomal dominant, neurodegenerative disorder
characterized by involuntary choreiform movements, cognitive decline and a progressive …

The different types of striatal neuron show a range of vulnerabilities to a variety of insults.
This can be clearly seen in Huntington's disease where a well mapped pattern of …

We used two mouse models of Huntington's disease (HD) to examine changes in glutamate
receptor sensitivity and striatal electrophysiology. One model, a transgenic, consisted of …

Intranuclear inclusion bodies are a shared pathological feature of Huntington's disease (HD)
and its transgenic mouse model. Using a panel of antibodies spanning the entire huntingtin …

To determine whether growth factors of the neurotrophin family are able to regulate the
phenotype of striatal projection neurons, cell lines overexpressing brain-derived …

The mRNA expression for preprotachykinin‐A (PPT‐A) was studied throughout the human
and cynomolgus monkey brain to assess the neuroanatomical expression pattern of the PPT …

The basal ganglia have long been singled out for studies of the chemical neuroanatomy of
the brain because of the rich variety of neurotransmitter, neuropeptide and aminergic …

Huntington's disease (HD) is a neurodegenerative disorder characterized by dyskinetic
abnormal movements and cognitive decline associated with progressive atrophy of the …

Metabolic compromise has been found to precede both neuronal loss and the appearance
of motoric and cognitive deficits in Huntington's disease (HD) patients. Studies using both …

Huntington's disease (HD) is a neurodegenerative disorder characterized by dyskinetic
abnormal movements and cognitive decline associated with progressive atrophy of the …