Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides

R Mentlein - Regulatory peptides, 1999 - Elsevier
Dipeptidyl-peptidase IV (DPP IV/CD26) has a dual function as a regulatory protease and as
a binding protein. Its role in the inactivation of bioactive peptides was recognized 20 years …

The glucagon-like peptides

TJ Kieffer, J Francis Habener - Endocrine reviews, 1999 - academic.oup.com
Glucagon-Like Peptides | Endocrine Reviews | Oxford Academic Skip to Main Content
Advertisement Oxford Academic Journals Books Search Menu Information Account Menu …

Glucagon-like peptide-1-(7–36) amide is transformed to glucagon-like peptide-1-(9–36) amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the …

L Hansen, CF Deacon, C Ørskov, JJ Holst - Endocrinology, 1999 - academic.oup.com
The insulinotropic hormone glucagon-like peptide-1 (GLP-1) is stored in the intestinal L cell
in an active form, GLP-1-(7–36) amide, but more than half of the endogenous peptide …

GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans

E Näslund, J Bogefors, S Skogar… - American Journal …, 1999 - journals.physiology.org
The aim of the present study was to assess the effect of glucagon-like peptide-1 (GLP-1) on
solid gastric emptying and the subsequent release of pancreatic and intestinal hormones. In …

Use of GLP-1 or analogs to abolish catabolic changes after surgery

S Efendic - US Patent 6,006,753, 1999 - Google Patents
US6006753A - Use of GLP-1 or analogs to abolish catabolic changes after surgery - Google
Patents US6006753A - Use of GLP-1 or analogs to abolish catabolic changes after surgery …

Glucagon-like peptide 1 (GLP-1): an intestinal hormone, signalling nutritional abundance, with an unusual therapeutic potential

JJ Holst - Trends in Endocrinology & Metabolism, 1999 - cell.com
The incretin hormone, glucagon-like peptide 1 (GLP-1) has many actions; namely:(1) it
enhances all steps of insulin biosynthesis and potentiates glucose-induced secretion;(2) it …

Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects

MF Kong, I Chapman, E Goble, J Wishart, G Wittert… - Peptides, 1999 - Elsevier
Oral glucose is a potent stimulant of glucagon-like peptide-1 (GLP-1) secretion. The effect of
oral fructose on GLP-1 secretion in humans is unknown. The aims of this study were to …

Is glucagon-like peptide 1 an incretin hormone?

MA Nauck - Diabetologia, 1999 - Springer
Summary Glucagon-like peptide-1 (GLP-1) was predicted, based on the proglucagon gene
sequence. It is synthesised by specific post-translational processing in L cells (lower …

Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1

R Burcelin, W Dolci, B Thorens - Metabolism, 1999 - Elsevier
Glucagon-like peptide-1 (7–37)(GLP-1) is the most potent insulinotropic hormone
characterized thus far. Because its activity is preserved in non-insulin-dependent diabetes …

Biological activity of GLP-1-analogues with N-terminal modifications

EG Siegel, B Gallwitz, G Scharf, R Mentlein… - Regulatory peptides, 1999 - Elsevier
Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion and improves glycemic control
in type 2 diabetes. In serum the peptide is degraded by dipeptidyl peptidase IV (DPP IV) …