Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature

SS Chang, VE Reuter, WDW Heston, NH Bander… - Cancer research, 1999 - AACR
Prostate-specific membrane antigen (PSMA) is a type II integral membrane glycoprotein that
was initially characterized by the monoclonal antibody (mAb) 7E11. PSMA is highly …

Prostate-specific membrane antigen is produced in tumor-associated neovasculature

SS Chang, DS O'Keefe, DJ Bacich, VE Reuter… - Clinical Cancer …, 1999 - AACR
Prostate-specific membrane antigen (PSMA), a type II transmembrane protein, was originally
thought to be strictly expressed in prostatic tissue, but recent studies have demonstrated …

Prostate-specific membrane antigen (PSMA)-specific monoclonal antibodies in the treatment of prostate and other cancers

MC Gong, SS Chang, M Sadelain, NH Bander… - Cancer and Metastasis …, 1999 - Springer
Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein that is expressed
by prostate epithelial cells. PSMA-specific monoclonal antibodies have been utilized to …

Isolation and expression of novel human glutamate carboxypeptidases with N-acetylated α-linked acidic dipeptidase and dipeptidyl peptidase IV activity

MN Pangalos, JM Neefs, M Somers… - Journal of Biological …, 1999 - ASBMB
Hydrolysis of the neuropeptideN-acetyl-l-aspartyl-l-glutamate (NAAG) by N-acetylated α-
linked acidic dipeptidase (NAALADase) to release glutamate may be important in a number …

Characterization of the enzymatic activity of PSM: comparison with brain NAALADase

CW Tiffany, RG Lapidus, A Merion, DC Calvin… - The …, 1999 - Wiley Online Library
BACKGROUND The prostate cancer marker prostate‐specific membrane antigen (PSM) is
highly homologous to the brain enzyme N‐acetylated alpha‐linked acidic dipeptidase …

Site-directed mutagenesis of predicted active site residues in glutamate carboxypeptidase II

HS Speno, R Luthi-Carter, WL Macias… - Molecular …, 1999 - ASPET
Glutamate carboxypeptidase II (GCP II) catalyzes the extracellular hydrolysis of the
neuromodulator N-acetyl-aspartylglutamate to N-acetyl-aspartate and glutamate. GCP II also …

Purification, cDNA Cloning, and Expression of a New Human Blood Plasma Glutamate Carboxypeptidase Homologous toN-Acetyl-aspartyl-α-glutamate …

R Gingras, C Richard, M El-Alfy, CR Morales… - Journal of Biological …, 1999 - ASBMB
We describe the identification, cDNA cloning, and biochemical characterization of a new
human blood plasma glutamate carboxypeptidase (PGCP). PGCP was co-purified from …

The extracellular regions of PSMA and the transferrin receptor contain an aminopeptidase domain: implications for drug design

D Mahadevan, JW Saldanha - Protein Science, 1999 - cambridge.org
The Aeromonas proteolytica aminopeptidase (AMP), Pseudomonas sp.(RS-16)
carboxypeptidase G2 (CPG2), and Streptomyces griseus aminopeptidase (SGAP) are zinc …

PSMA mimotope isolated from phage displayed peptide library can induce PSMA specific immune response

ZY ZHU, CP ZHONG, WF XU, GM LIN, GQ YE, YY JI… - Cell Research, 1999 - nature.com
Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein expressed
predominantly in prostate secretory acinar epithelium and prostate cancer cells as well as in …

Antifolate polyglutamylation in preclinical and clinical antifolate resistance

JJ McGuire - Antifolate drugs in cancer therapy, 1999 - Springer
The folates, a family of essential human vitamins, are cofactors in one-carbon transfer
reactions, including those in the synthesis of serine, glycine, methionine, purines, and …