Glutamic acid is the principal excitatory neurotransmitter in the mammalian central nervous
system. Glutamic acid binds to a variety of excitatory amino acid receptors, which are ligand …

Contemporary models of major depression emphasize the role of hypothalamic-pituitary-
adrenal (HPA)-axis hyperactivity and of dysfunctions in the turnover of serotonin (5-HT) or …

The synthesis of NAD (or NADP) from tryptophan involves a series of enzymes and the
formation of a number of intermediates which are collectively calledkynurenines.'In the late …

Abstract The heme enzyme indoleamine 2, 3-dioxygenase (IDO) oxidizes the pyrrole moiety
of L-tryptophan (Trp) and other indoleamines and represents the initial and rate-limiting …

Objectives: To compare the kinetics and magnitude of HIV-1 RNA responses to antiretroviral
therapy (ART) in the cerebrospinal fluid (CSF) and plasma. Design: Repeated lumbar …

The pathobiology of dementia that accompanies infection with the human immunodeficiency
virus involves complex interactions of the virus with the host. The virus enters the brain either …

In patients with neurodegenerative disorders, namely Alzheimer's disease and Huntington's
disease, we compared serum concentrations of tryptophan, kynurenine and the kynurenine …

The parent pyridine nucleotide NAD is the end product of oxidative tryptophan catabolism
via the kynurenine pathway. Indoleamine 2, 3-dioxygenase, the rate-limiting enzyme for this …

Quinolinic acid, α-picolinic acid, fusaric acid, and 2, 6-pyridinedicarboxylic acid enhanced
the Fenton reaction in phosphate buffer, respectively. The enhancement by quinolinic acid, α …

Quinolinic acid in the cerebrospinal fluid of children after... : Critical Care Medicine Quinolinic
acid in the cerebrospinal fluid of children after traumatic brain injury : Critical Care Medicine …