The bromodomain is an∼ 110 amino acid module found in histone acetyltransferases and
the ATPase component of certain nucleosome remodelling complexes. We report the crystal …

Histone acetylation correlates well with transcriptional activity, and histone
acetyltransferases (HATs) selectively regulate subsets of target genes by mechanisms that …

The Hoxb1 autoregulatory element comprises three HOX-PBX binding sites. Despite the
presence of HOXB1 and PBX1, this enhancer fails to activate reporter gene expression in …

Esa1 is the catalytic subunit of the NuA4 histone acetylase (HAT) complex that acetylates
histone H4, and it is a member of the MYST family of HAT proteins that includes the MOZ …

Chromatin structure has a pivotal role in the regulation of gene expression. Transcriptional
activation or the repression of a gene require the recruitment of multiple chromatin …

Targeted alterations in the nucleoprotein fibre of chromatin represent a major mechanism of
gene control in eukarya, and the aetiology of a large number of human pathological …

Molecular mechanisms controlling gene expression include cell shape, mechanical and
chemical signal transduction pathways, chromatin remodeling, and DNA methylation. In this …

Thyroid hormone resistance (RTH) is a rare autosomal dominant disorder, characterized
clinically by goiter and biochemically by elevated circulating free thyroid hormone levels in …

The past ten years or so have seen many global boundaries come down—from economic
and geographical borders to the Berlin wall. This is the case in science too, where the lines …

Transcription initiation in the eukaryotic cell is a complex process which requires multiple
protein-DNA and protein-protein contacts to be established. In addition, the access of …