Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin αIIbβ3
W Puzon-McLaughlin, T Kamata, Y Takada - Journal of Biological …, 2000 - ASBMB
Integrin α IIb β 3, a platelet fibrinogen receptor, is critically involved in thrombosis and
hemostasis. However, how ligands interact with α IIb β 3 has been controversial. Ligand …
hemostasis. However, how ligands interact with α IIb β 3 has been controversial. Ligand …
A naturally occurring mutation near the amino terminus of αIIb defines a new region involved in ligand binding to αIIbβ3
RB Basani, DL French, G Vilaire… - Blood, The Journal …, 2000 - ashpublications.org
Decreased expression of functional IIbβ3 complexes on the platelet surface produces
Glanzmann thrombasthenia. We have identified mutations of IIbP145 in 3 ethnically distinct …
Glanzmann thrombasthenia. We have identified mutations of IIbP145 in 3 ethnically distinct …
Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway
RL Roll, EM Bauman, JS Bennett… - The Journal of cell …, 2000 - rupress.org
Pleckstrin is a 40-kD phosphoprotein containing NH2-and COOH-terminal pleckstrin
homology (PH) domains separated by a disheveled-egl 10-pleckstrin (DEP) domain. After …
homology (PH) domains separated by a disheveled-egl 10-pleckstrin (DEP) domain. After …
Expression and function of calcium binding domain chimeras of the integrins αIIb and α5
S Gidwitz, S Lyman, GC White - Journal of Biological Chemistry, 2000 - ASBMB
To further identify amino acid domains involved in the ligand binding specificity of α IIb β 3,
chimeras of the conserved calcium binding domains of α IIb and the α subunit of the …
chimeras of the conserved calcium binding domains of α IIb and the α subunit of the …