The past twenty years have seen great strides in our understanding of the molecular
regulation of differentiation for a whole host of specific cell types. The development of …

In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and
cancer are responsible for most deaths. These ailments have complex causes involving …

Dietary fat intake is an environmental factor that affects many aspects of human health. 1
Several lines of evidence suggest that common diseases of modern society are associated …

▪ Abstract Adipogenesis, or the development of fat cells from preadipocytes, has been one of
the most intensely studied models of cellular differentiation. In part this has been because of …

The peroxisome proliferator–activated receptor γ (PPARγ) is a nuclear receptor that
regulates fat-cell development and glucose homeostasis and is the molecular target of a …

To determine the physiological roles of peroxisome proliferator-activated receptor β
(PPARβ), null mice were constructed by targeted disruption of the ligand binding domain of …

The nuclear receptor peroxisome proliferator-activated receptor γ regulates adipose
differentiation and systemic insulin signaling via ligand-dependent transcriptional activation …

The recent development of a novel class of insulin-sensitizing drugs, the thiazolidinediones
(TZDs), represents a significant advance in antidiabetic therapy. One key mechanism by …

Recent advances regarding the biology of adipose tissue have identified the adipocyte as
an important mediator in many physiologic and pathologic processes regarding energy …

The nuclear hormone receptor peroxisome proliferator-activated receptor (PPAR) γ is a
ligand-activated transcription factor that regulates several crucial biological processes such …