This paper reviews the major anatomical and chemical features of the various types of
interneurons in the human striatum, as detected by immunostaining procedures applied to …

Huntington's disease is an inherited neurodegenerative disorder, the cause of which is
unknown. Excitotoxicity, mitochondrial dysfunction and oxidative stress are all likely to …

In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of
dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a …

Intrastriatal injection of quinolinate has been proven to be a very useful animal model to
study the pathogenesis and treatment of Huntington's disease. To determine whether growth …

Huntington's disease is a devastating progressive neurodegenerative illness characterized
by massive neuronal loss in the striatum. It is caused by the presence of an expanded CAG …

The various types of striatal projection neurons and interneurons show a differential pattern
of loss in Huntington's disease (HD). Since striatal injury has been suggested to involve …

Toward an understanding of the mechanisms controlling Preprotachykinin-A (PPTA)
transcription, we introduced a 380-kb human yeast artificial chromosome containing the …

Metabolic compromise has been found to precede both neuronal loss and the appearance
of motoric and cognitive deficits in Huntington's disease (HD) patients. Studies using both …