γ-Glutamyl hydrolase (GH, EC 3.4. 19.9) is a lysosomal and secreted glycoprotein that
hydrolyzes the γ-glutamyl tail of antifolate and folate polyglutamates. Tumor cells that have …

BACKGROUND Prostate‐specific membrane antigen (PSMA) is a 750‐residue integral
membrane glycoprotein and the target of an in‐vivo imaging agent for metastatic prostate …

Prostate-specific membrane antigen (PSMA) is an approximately 100-kDa type II membrane
protein originally characterized by the monoclonal antibody (mAb) 7E11 and expressed in …

Low blood folate levels result in hyperhomocysteinemia, which has been associated with
increased risk for cardiovascular disease, neural tube defects and cognitive deficits. Intake …

BACKGROUND Prostate‐specific membrane antigen (PSMA) is a glutamate
carboxypeptidase that cleaves terminal carboxy glutamates from both the neuronal …

BACKGROUND This study determined the effects of S‐allylmercaptocysteine (SAMC), a
phytoconstituent from garlic, on the expression of androgen‐responsive biomarkers …

The expression of Prostate-specific membrane antigen (PSMA) mRNA was assessed in the
normal bladder urothelium (n= 9), transitional cell carcinoma (TCC) specimens (n= 52), TCC …

BACKGROUND Prostate specific membrane antigen (PSMA) is a transmembrane
glycoprotein highly expressed in benign prostate secretory‐acinar epithelium and prostate …

Publisher Summary This chapter discusses the cellular and molecular aspects of intestinal
absorption and regulation of water-soluble vitamins. The water-soluble vitamins represent a …

The antifolate methotrexate (MTX) is widely used in cancer chemotherapy. In this study, we
show that MTX (MTX‐Glu1) and MTX‐polyglutamates (MTX‐Glu2—5) strongly inhibited the …