Chaperones/heat shock proteins (HSPs) of the HSP90 and HSP70 families show elevated
levels in proliferating mammalian cells and a cell cycle‐dependent expression. They …

Vitamin A, its physiologic metabolites, and synthetic derivatives (retinoids) have been shown
to have protective effects against the development of certain types of cancer. In addition …

Cadmium (Cd), a human carcinogen, can induce apoptosis in various cell types. Three
major mitogen-activated protein kinases (MAPKs), c-JUN N-terminal kinase (JNK), p38 and …

We investigated the capacity of 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3] and all-trans-
retinoic acid (ATRA) to sensitize three breast cancer cell lines to the cell killing effects of …

Carcinogenesis is a multistep process that converts normal cells into malignant cells. Once
transformed, malignant cells acquire the ability to invade and metastasize, leading to …

In this study we have explored the involvement of oxidative stress in Cr (VI)-induced JNK,
p38 and ERK signaling pathways and their effects on Cr (VI) cytotoxicity in human non-small …

Differentiation therapy for neoplastic diseases has potential for supplementing existing
treatment modalities but its implementation has been slow. One of the reasons is the lack of …

Vitamin A, its physiological metabolites and synthetic derivatives (retinoids) have been
shown to have protective effects against the development of certain types of cancer. In …

Retinoids are known to induce the differentiation and cell cycle arrest of human myeloid
leukemia cells in vitro. Differential display was used to identify putative early regulatory …

Retinoic acid is known to cause the myeloid differentiation and G1/0 cell cycle arrest of HL-
60 cells in a process that requires mitogen-activated protein/extracellular signal regulated …