Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …

▪ Abstract Transcriptional regulation in eukaryotes occurs within a chromatin setting and is
strongly influenced by nucleosomal barriers imposed by histone proteins. Among the well …

The NAD-dependent histone deacetylation of Sir2 connects cellular metabolism with gene
silencing as well as aging in yeast. Here, we show that mammalian Sir2α physically interacts …

In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …

The nuclear expression and action of the nuclear factor kappa B (NF-κB) transcription factor
requires signal-coupled phosphorylation and degradation of the IκB inhibitors, which …

CREB1-binding protein (CBP) and p300 are believed to participate in the activities of
hundreds of different transcription factors (see Fig. 1). Current models suggest that the …

Post-translational addition of methyl groups to the amino-terminal tails of histone proteins
was discovered more than three decades ago. Only now, however, is the biological …

Cellular DNA damage causes stabilization and activation of the tumor suppressor and
transcription factor p53, in part by promoting multiple covalent modifications of the p53 …

Histone acetyltransferases (HATs) directly link chromatin modification to gene activation.
Recent structure/function studies provide insights into HAT catalysis and histone binding …

YY1 is a sequence-specific DNA-binding transcription factor that has many important
biological roles. It activates or represses many genes during cell growth and differentiation …