Neuroinflammation and the genetics of Alzheimer's disease: the search for a pro-inflammatory phenotype
The role of interleukin 1 (IL-1) and interleukin 6 (IL-6) in the pathogenesis of Alzheimer's
disease (AD) is reviewed within the framework of “inflammaging”, ie, the characteristic …
disease (AD) is reviewed within the framework of “inflammaging”, ie, the characteristic …
Recent advances in human gene–longevity association studies
G De Benedictis, Q Tan, B Jeune, K Christensen… - Mechanisms of ageing …, 2001 - Elsevier
This paper reviews the recent literature on genes and longevity. The influence of genes on
human life span has been confirmed in studies of life span correlation between related …
human life span has been confirmed in studies of life span correlation between related …
Low insulin resistance and preserved β-cell function contribute to human longevity but are not associated with TH–INS genes
G Paolisso, M Barbieri, MR Rizzo, C Carella… - Experimental …, 2001 - Elsevier
Tyrosine Hydroxylase (TH) and Insulin (INS) genes lie extremely close in the 11p15. 5
chromosomal region. An STR marker of the TH gene had revealed this locus associated with …
chromosomal region. An STR marker of the TH gene had revealed this locus associated with …
Applying hormesis in aging research and therapy
SIS Rattan - Human & experimental toxicology, 2001 - journals.sagepub.com
Biology of aging is well understood at a descriptive level. Based on these data,
biogerontological research is now able to develop various possibilities for intervention. A …
biogerontological research is now able to develop various possibilities for intervention. A …
A stochastic model for CD8+ T cell dynamics in human immunosenescence: implications for survival and longevity
F Luciani, S Valensin, R Vescovini, P Sansoni… - Journal of Theoretical …, 2001 - Elsevier
We propose here a stochastic model for the CD 8+ T lymphocyte dynamics on the long time-
scale of the human lifespan. Our purpose has been to test the hypothesis, recently proposed …
scale of the human lifespan. Our purpose has been to test the hypothesis, recently proposed …
Increase of homozygosity in centenarians revealed by a new inter-Alu PCR technique
M Bonafè, M Cardelli, F Marchegiani… - Experimental …, 2001 - Elsevier
In the present study a novel inter-Alu PCR technique that allows one to detect inter-
individual differences in the genomic regions flanked by Alu repetitive sequences was …
individual differences in the genomic regions flanked by Alu repetitive sequences was …