Extracellular proteolysis is an absolute requirement for new blood vessel formation, a
process known as angiogenesis. This review will examine the role of the matrix …

Basement membrane molecules and fragments derived from them are regulators of
biological activities such as cell growth, differentiation and migration. This review describes …

The American Society for Testing and Materials (ASTM) is making a concerted effort to
establish standards and guidelines for the entire field of tissue‐engineered medical products …

The current study describes new, antivascular, and antitumor effects of human endostatin. A
novel system for continuous, localized delivery of antiangiogenic compounds to brain tumors …

Gene therapy using viral vectors has to date failed to reveal its definitive clinical usefulness.
Cell encapsulation technology represents an alternative, nonviral approach for the delivery …

Malignant ascites is a common complication of advanced intraabdominal neoplasms for
which standard treatments are suboptimal. Evidence suggests that tumor-mediated …

Background: Inhibiting tumor angiogenesis is a promising new strategy for treating cancer.
Difficulties with the stability, manufacture, and long-term administration of recombinant …

The structure of DNA was unraveled by Watson and Crick in 1953, and two decades later
Arber, Nathans and Smith discovered DNA restriction enzymes which led to the rapid growth …

New genetic models provide better biological mimics of human tumors. The new models can
give deeper insight into tumorigenesis and provide better targets for testing therapies. To …

Alginate microcapsules may be used to encapsulate therapeutic cells and, thereby, to
protect them from the host immune system. Both the biomaterial, as well as the therapeutic …