The selective vulnerability of nerve cells in Huntington's disease

KA Sieradzan, DMA Mann - Neuropathology and applied …, 2001 - Wiley Online Library
It is now more than 7 years since the genetic mutation causing Huntington's disease (HD)
was first identified. Unstable CAG expansion in the IT15 gene, responsible for disease, is …

Open interconnected model of basal ganglia‐thalamocortical circuitry and its relevance to the clinical syndrome of Huntington's disease

D Joel - Movement disorders: official journal of the Movement …, 2001 - Wiley Online Library
The early stages of Huntington's disease (HD) present with motor, cognitive, and emotional
symptoms. Correspondingly, current models implicate dysfunction of the motor, associative …

Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice

H Li, SH Li, ZX Yu, P Shelbourne… - Journal of Neuroscience, 2001 - Soc Neuroscience
Huntington's disease (HD) is characterized by the selective loss of striatal projection
neurons. In early stages of HD, neurodegeneration preferentially occurs in the lateral globus …

NMDA receptor function in mouse models of Huntington disease

C Cepeda, MA Ariano, CR Calvert… - Journal of …, 2001 - Wiley Online Library
Huntington disease (HD) is an autosomal dominant disorder in which degeneration of
medium‐sized spiny striatal neurons occurs. The HD gene and the protein it encodes …

Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disorders

LE Haynes, MR Griffiths, RE Hyde, DJ Barber… - Neuroscience, 2001 - Elsevier
It has been shown previously that the synthetic corticosteroid dexamethasone induces
apoptosis of granule cells in the dentate gyrus and striatopallidal neurons in the …

Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area

JM Canals, N Checa, S Marco, P Åkerud… - Journal of …, 2001 - Soc Neuroscience
Changes in BDNF expression after different types of brain insults are related to
neuroprotection, stimulation of sprouting, and synaptic reorganization. In the cerebral cortex …

Chorea and its disorders

DS Higgins - Neurologic clinics, 2001 - neurologic.theclinics.com
Chorea (Greek for" dance") refers to irregular, rapid, flowing, nonstereotyped, and random
involuntary movements that often possess a writhing quality, referred to as choreoathetosis …

[PDF][PDF] A Murine Model of Genetic and Environmental Neurotoxicant Action DAMD17-98

EK Richfield - 2001 - Citeseer
The subject of this research is to understand the role of genes, aging, and neurotoxicants on
the etiology of Parkinson's disease (PD). One specific gene, the human cx-synuclein gene …

[图书][B] An inducible model of Huntington's disease

A Yamamoto - 2001 - search.proquest.com
Huntington's disease (HD) is an inheritable neurodegenerative disorder caused by a
pathogenic polyglutamine expansion in the protein huntingtin. It is characterized by …