With possibly incomplete nuclear families, the family based association test (FBAT) method
allows one to evaluate any test statistic that can be expressed as the sum of products …

Multiple lines of evidence have implicated the short arm of chromosome 8 as harboring
genes important in prostate carcinogenesis. Although most of this evidence comes from the …

To investigate the relationship between HPC2/ELAC2 and prostate cancer risk, we
performed the following analyses:(1) a linkage study of six markers in and around the …

Attention-deficit hyperactivity disorder (ADHD) subtypes in DSM-IV are defined by the
presence of 6 or more inattentive and/or the presence of 6 or more hyperactive/impulsive …

Dopamine pathway genes have been the subject of a variety of studies testing the
association of candidate genes and liability for attention‐deficit hyperactivity disorder …

Genes influence the development of anxiety disorders, but the specific loci involved are not
known. Genetic association studies of anxiety disorders are complicated by the complexity of …

Androgens are essential for prostate development, growth and maintenance and the
association between androgen levels and prostate cancer is well established. Since the …

In this paper we describe various study designs and analytic techniques for testing the joint
hypothesis that a genetic marker is both linked to and associated with a quantitative …

The autoimmune thyroid diseases (AITDs) including Graves' disease and Hashimoto's
thyroiditis are inherited as complex traits. We have performed linkage and association …

This work has two purposes:(i) empirically selecting levels of significance that maximize the
fraction of markers close to a gene (hit rate) when performing linkage analyses of simulated …