Recent epidemiological and clinico-pathologic data suggest overlaps between Alzheimer
disease (AD) and cerebrovascular lesions that may magnify the effect of mild AD pathology …

RPTPσ is a cell adhesion molecule-like receptor protein tyrosine phosphatase involved in
nervous system development. Its avian orthologue, known as cPTPσ or CRYPα, promotes …

The quality of the blood-brain barrier (BBB), represented mainly by endothelial tight
junctions (TJ), is now believed to be dependent on the brain microenvironment and …

APOE4 homozygosity has been associated with an increased risk of sporadic Alzheimer's
disease through a mechanism, which has yet to be defined. Recent evidence has suggested …

Factor H, a regulatory protein of the alternative pathway of complement (APC), is present in
amyloid-β (Aβ) plaques in Alzheimer's disease (AD). Aβ plaques also contain significant …

The extracellular matrix molecule agrin mediates the motor neuron induced accumulation of
acetylcholine receptors (AChR) at the neuromuscular junction. Agrin is also present in the …

Alzheimer's disease (AD) brains are characterized by the presence of senile plaques (SPs),
which primarily consist of amyloid β protein (Aβ). Besides Aβ, several other proteins with the …

Agrin mediates motor neuron-induced differentiation of the postsynaptic apparatus of the
neuromuscular junction but its function in brain remains unknown. Here we report that …

Homeostasis of the extracellular microenvironment in the neural tissue of the brain as well
as its protection against neurotoxic compounds and variations in the composition of the …

Agrin and Microvascular Damage in Alzheimer's Disease Page 1 202 Agrin and Microvascular
Damage in Alzheimer's Disease YSeeAeeAeS Jason A. Peck, MD and Edward G. Stopa, MD …