Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …

Extensive research on humans suggests that exercise could have benefits for overall health
and cognitive function, particularly in later life. Recent studies using animal models have …

Previous studies demonstrated that antidepressant treatment increases the expression of
brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was …

Recent findings with animal models have suggested a possible role for brain-derived
neurotrophic factor (BDNF) in depression. We have therefore hypothesized that depression …

One of the most rigorously investigated problems in modern neuroscience is to decipher the
mechanisms by which experience-induced changes in the central nervous system are …

In this fully-revised fourth edition of what has long been the standard textbook for the field,
Dr. Richard Abrams once again demonstrates his unique ability to analyze and present a …

The γ-aminobutyric acidB (GABAB) receptor was first demonstrated on presynaptic terminals
where it serves as an autoreceptor and also as a heteroreceptor to influence transmitter …

OBJECTIVE: Previous work suggests that patients with unipolar depression may have
structural as well as functional abnormalities in limbic-thalamic-cortical networks, which are …

Objective: We review the literature on the cellular changes that underlie the structural
impairments observed in brains of animals exposed to stress and in subjects with …

Bipolar disorder (BP) is a severe psychiatric disease, with a strong genetic component, that
affects 1% of the population worldwide and is characterized by recurrent episodes of mania …