Activation of integrin αIIbß3 by modulation of transmembrane helix associations
R Li, N Mitra, H Gratkowski, G Vilaire, R Litvinov… - Science, 2003 - science.org
Transmembrane helices of integrin α and β subunits have been implicated in the regulation
of integrin activity. Two mutations, glycine-708 to asparagine-708 (G708N) and methionine …
of integrin activity. Two mutations, glycine-708 to asparagine-708 (G708N) and methionine …
Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty
DE Mager, MA Mascelli, NS Kleiman… - … of Pharmacology and …, 2003 - ASPET
An integrated structural pharmacokinetic/pharmacodynamic (PK/PD) model was developed
for the glycoprotein IIb/IIIa antagonist abciximab administered to patients undergoing …
for the glycoprotein IIb/IIIa antagonist abciximab administered to patients undergoing …
[HTML][HTML] CD32-mediated platelet aggregation in vitro by anti-thymocyte globulin: implication of therapy-induced in vivo thrombocytopenia
HJ Ankersmit, GA Roth, B Moser, A Zuckermann… - American Journal of …, 2003 - Elsevier
Induction therapy with polyclonal antithymocyte‐globulin (ATG) is widely used in the
prophylaxis and treatment of acute cardiac‐allograft rejection. Thrombocytopenia, however …
prophylaxis and treatment of acute cardiac‐allograft rejection. Thrombocytopenia, however …