The BRCA1 gene was identified and cloned in 1994 based its linkage to early onset breast
cancer and breast‐ovarian cancer syndromes in women. While inherited mutations of …

The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from
the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and …

We have cloned four human cDNAs encoding putative cysteine proteinases that have been
tentatively called autophagins. These proteins are similar to Apg4/Aut2, a yeast enzyme …

USP7 or HAUSP is a ubiquitin-specific protease in human cells that regulates the turnover of
p53 and is bound by at least two viral proteins, the ICP0 protein of herpes simplex type 1 …

Ubiquitination of proteins is now recognized to target proteins for degradation by the
proteasome and for internalization into the lysosomal system, as well as to modify functions …

Modification of proteins by the covalent attachment of ubiquitin is a key regulatory
mechanism of many cellular processes including protein degradation by the 26S pro …

The BRCA1 tumor suppressor has been implicated in the maintenance of chromosomal
stability through homology-directed repair of DNA double-strand breaks. Much of the BRCA1 …

Covalent modification of proteins with ubiquitin regulates almost all aspects of eukaryotic
cellular function. Ubiquitin protein ligases (E3s) play central regulatory roles in that they …

Mutations of BRCA1 gene are associated with more than half the cases of hereditary breast
cancer. Breast cancer formation in BRCA1 mutation carriers is generally accompanied by …

[Frontiers in Bioscience 8, s1107-1117, September 1, 2003] 1107 BRCA1 IN CANCER, CELL
CYCLE AND GENOMIC STABILITY Meena Jhanwar- Page 1 [Frontiers in Bioscience 8 …