[Frontiers in Bioscience 8, d369-391, January 1, 2003] 369 MITOGEN-ACTIVATED PROTEIN
KINASE PATHWAYS IN REDOX SIGNALING Martine Page 1 [Frontiers in Bioscience 8 …

Evidence of oxidative stress is apparent in both acute and chronic neurodegenerative
diseases, such as stroke, Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) …

The mechanisms through which estrogen prevents bone loss are uncertain. Elsewhere,
estrogen exerts beneficial actions by suppression of reactive oxygen species (ROS). ROS …

The main purpose of this study was to determine whether the aging process in the mouse is
associated with a pro-oxidizing shift in the redox state of glutathione and whether restriction …

Dietary use of curcumin, the active component of tumeric, one of the most widely used
spices, is linked to several beneficial health effects, although the underlying molecular …

Reactive oxygen species and various electrophiles are involved in the etiology of diseases
varying from cancer to cardiovascular and pulmonary disorders. The human body is …

The senescence‐accelerated mouse (SAM) is a useful animal model to study aging or age‐
associated disorders due to its inherited aging phenotype. To investigate proteins involved …

Objective Intracellular glutathione in its reduced state is a principal cellular biomolecule with
antioxidant activity. Glutathione and homocysteine metabolism are closely associated. As …

Glutamate-cysteine ligase (GCL) has a key influence on glutathione homeostasis. It has
been proposed that mammalian GCL is regulated by the redox environment, and we show …

Current evidence demonstrates that protein kinase C (PKC) belongs to a group of cell-
signaling molecules that are sensitive targets for redox modifications and functional …