Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics
D Blum, R Hourez, MC Galas, P Popoli… - The Lancet …, 2003 - thelancet.com
Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder, the
progression of which cannot be prevented by any neuroprotective approach, despite major …
progression of which cannot be prevented by any neuroprotective approach, despite major …
The use of transgenic and knock-in mice to study Huntington's disease
MA Hickey, MF Chesselet - Cytogenetic and genome research, 2003 - karger.com
The trinucleotide repeat disorders comprise an ever expanding list of diseases, all of which
are caused by an unstable expanded trinucleotide repeat tract. Huntington's disease (HD) is …
are caused by an unstable expanded trinucleotide repeat tract. Huntington's disease (HD) is …
Predictors of neuropathological severity in 100 patients with Huntington's disease
A Rosenblatt, MH Abbott, LM Gourley… - Annals of Neurology …, 2003 - Wiley Online Library
Subjects were followed in the Longitudinal Core Study of the Baltimore Huntington's
Disease Center and given annual neurological, cognitive, and psychiatric examinations …
Disease Center and given annual neurological, cognitive, and psychiatric examinations …
Enkephalinergic striatal projection neurons become less affected by quinolinic acid than substance P-containing striatal projection neurons as rats age
Z Sun, Q Chen, A Reiner - Experimental neurology, 2003 - Elsevier
While the excitotoxic vulnerability of striatal neurons is known to be greater in juvenile than
adult animals, it is uncertain if striatal neuron types decline differentially in their vulnerability …
adult animals, it is uncertain if striatal neuron types decline differentially in their vulnerability …
Therapeutic strategies in Huntington's disease
J Alberch, JM Canals… - Expert Opinion on …, 2003 - Taylor & Francis
The pathophysiology of Huntington's disease (HD) is not well understood because the
mechanisms triggered by mutant Huntingtin to induce selective neuronal death in the …
mechanisms triggered by mutant Huntingtin to induce selective neuronal death in the …