▪ Abstract Genomes are organized into active regions known as euchromatin and inactive
regions known as heterochromatin, or silenced chromatin. This review describes …

For almost 70 years, calorie restriction has been known to extend life span. Despite the
extensive physiological characterization of this dietary regimen, the molecular basis for the …

In diverse organisms, calorie restriction slows the pace of ageing and increases maximum
lifespan. In the budding yeast Saccharomyces cerevisia e, calorie restriction extends …

Calorie restriction extends lifespan in a broad range of organisms, from yeasts to mammals.
Numerous hypotheses have been proposed to explain this phenomenon, including …

Carbonylated proteins were visualized in single cells of the budding yeast Saccharomyces
cerevisiae, revealing that they accumulate with replicative age. Furthermore, carbonylated …

Very few gene conversions in mitotic cells are associated with crossovers, suggesting that
these events are regulated. This may be important for the maintenance of genetic stability …

The formation of complexes between proteins and ligands is fundamental to biological
processes at the molecular level. Manipulation of molecular recognition between ligands …

The human sirtuin 3 (SIRT3) gene encodes a putative mitochondrial NAD-dependent
deacetylase (SIRT3) which belongs to the evolutionary conserved family of sirtuin 2 proteins …

It is speculated that the function of the replication fork barrier (RFB) site is to avoid collision
between the 35S rDNA transcription machinery and the DNA replication fork, because the …

When it was first proposed that the budding yeast Saccharomyces cerevisiae might serve as
a model for human aging in 1959, the suggestion was met with considerable skepticism …